Gloucester reached their fifth Challenge Cup final after beating Italian side Benetton 40-23 at Kingsholm.
The Cherry Whites will face the Sharks at Tottenham Hotspur Stadium on Saturday, May 24, with the South Africans narrowly beating French side Clermont 32-31 in the first semi-final.
Gloucester won this event in the 2005/06 and 2014/15 seasons and finished second consecutively in the 2016/17 and 2017/18 seasons.
They have struggled in the Gallagher Premiership this season, losing 12 of 16 games and recording just four wins, ahead of Newcastle, the only team without a win.
But after beating Leicester Tigers 23-13 to win the Premiership Rugby Cup in March, they are now targeting a second title of the season.
Hastings stars as Gloucester beats Benetton
Forward Adam Hastings was a key figure in Gloucester’s victory over Benetton, adding 17 points from one shot, three conversions and two penalties in his penultimate home game before rejoining Glasgow this summer.
Linebackers Josh Hathaway, hooker Seb Black, tight end Freddy Clark and tight end Ollie Soli also scored touchdowns, while fullback Caolan Englefield converted a penalty kick with 10 minutes to go.
Benetton, who reached the Challenge Cup semi-finals last season, launched a furious attack against Gloucester when hooker Gianmarco Lucchesi (2) and full-back Rhyno Smith scored on goal attack.
shark Earlier, they reached the final with a stunning comeback victory over Clermont in a thriller at The Stoop.
The Sharks trailed 31-18 entering the final quarter, with only shots from Vincent Koch and Makazo Mapimpi turning the tide, with Mapimpi ) After scoring in the 71st minute, fly-half Siya Masuku scored the decisive goal.
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